In order to maintain homeostasis. mature cells removed from the top compartment of hierarchical tissues have to be replenished by means of differentiation and self-renewal events happening in the more primitive compartments. As each cell division is associated with a risk of mutation. cell division patterns have to be optimized. https://www.roneverhart.com/Jumbo-Gourmet-Wok-Tava-26-cm/
Optimizing homeostatic cell renewal in hierarchical tissues.
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